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Embryo incubation and the selection of embryos is a critical step in IVF treatments. Esco for years have supported customers worldwide with a highly accurate, reliable and completely certified incubator with MIRI® Multiroom Incubator, actually with more than 1,500 units installed worldwide.
Based on this proven technology and following the concept of individual chamber incubation MIRI® Time-Lapse Incubator provide the same accuracy in securing a stable and safe embryo culture environment, but adding the multiple features of time-lapse imaging.
Esco therefore believes that time-lapse systems play a vital role and should be considered a valuable tool to obtain the best clinical IVF outcome. By combining the effects of non-invasive embryo culture with the continuous surveillance of embryo development and it's sophisticated and highly informative tools which allow the embryologists to make a decision to select the most viable embryo for transfer and cryopreservation.
Scientific benefits from doing Time-Lapse?
Advantages like small individual chambers, an outstanding gas mixer, HEPA/VOC filtration and optional continuous pH monitoring seem to be obvious reasons for choosing a MIRI® TL but where does science say in regards to the use of time-lapse?
A recent meta-analysis of randomized controlled trials comparing the use of time-lapse system with traditional embryo incubation show a significant contribution to increase the ongoing clinical pregnancy and live birth rates, and reduce the early pregnancy loss.
The extensive review of the meta-analysis supports the benefits of the time-lapse system in the clinical IVF treatments;
- Application of time-lapse system significantly increases ongoing pregnancy rate
- Application of time-lapse system significantly decreases early pregnancy loss
- Application of time-lapse system significantly increases live birth rate
A comprehensive analysis showed the application of time-lapse system significantly improved the ongoing pregnancy and live birth rates (51% and 44.2%, respectively), compared with traditional incubation and evaluation (39.9% and 31.3%, respectively). In addition, meta-analysis on live birth rates have been recently updated to strengthen the positive effect of time-lapse system on live birth, adding up to 1945 cases (OR: 1.56; CI = 1.30-1.88; P < 0.001).
Early pregnancy loss rate was also significantly reduced with the application of time-lapse system to 15.3%.
This robust meta-analysis findings show the growing evidence for its benefits of using time-lapse system in clinical IVF. The benefits of changing from traditional embryo assessment to continuous observation using time-lapse system are also certainly supported by the findings. In conclusion, the effects of using time-lapse system significantly contribute the reduction in early pregnancy loss, higher ongoing pregnancy and live birth rates with the potential to shorten the time to pregnancy.